Reality check for malaria proteomics

Reality check for checklists.

Catheter-related blood stream infections in the intensive care unit (ICU) are common, costly, and potentially lethal. The Dec 28, 2006, issue of The New England Journal of Medicine reported that an evidence-based intervention in 103 intensive care units in the Michigan Keystone ICU programme had resulted in a large sustained reduction in rates of these infections. The study was widely reported ...

Reality check for American dream.

A Reality Check For Data Snooping

A Reality-Check for Putative Stem Cells

The concept of using stem cells for cardiovascular repair holds great potential, but uncertainties in preclinical experiments must be addressed before their therapeutic application. Contemporary proteomic techniques can help to characterize cell preparations more thoroughly and identify some of the potential causes that may lead to a high failure rate in clinical trials. The first part of this ...

A reality check for alignments and trees.

Making multiple sequence alignments is one of the more commonplace procedures in modern biology. Multiple alignments are typically generated by feeding sequences into the alignment program from the N-terminus to the C-terminus. Recent results show that if the same sequences are processed from the C- to the N-terminus, a different alignment is often obtained. Because phylogenetic trees are built...